Attenuation of Murine Graft-Versus-Host Disease by a Tea Polyphenol

Since donor T-cells' allorecognition of host antigens is a prerequisite for the onset of graft-versus-host disease (GVHD), blocking their cellular signaling pathways can decrease the severity of GVHD. We hypothesized that epigallocatechin-3-gallate (EGCG), due to its strong affinity to macromol...

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Bibliographic Details
Main Authors: Jun Kanamune, Yasuhiro Iwanaga, Tatsuo Kina, Hirofumi Noguchi, Kazuaki Matsumura, Shinji Uemoto, Suong-Hyu Hyon
Format: Article
Language:English
Published: SAGE Publishing 2012-05-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368911X623934