Levetiracetam reverses synaptic deficits produced by overexpression of SV2A.

Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the synaptic vesicle protein SV2A, how drug binding affects synaptic functioning remains unknown. Here we report that levetiracetam reverses the effec...

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Bibliographic Details
Main Authors: Amy Nowack, Erik B Malarkey, Jia Yao, Adam Bleckert, Jessica Hill, Sandra M Bajjalieh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248421?pdf=render