Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

CRISPR-Cas systems provide bacteria and archaea with programmable immunity against mobile genetic elements. Evolutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-CRISPRs (Acrs), that block Cas enzyme function by wide-ranging mechanisms. We show here th...

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Bibliographic Details
Main Authors: Gavin J Knott, Brady F Cress, Jun-Jie Liu, Brittney W Thornton, Rachel J Lew, Basem Al-Shayeb, Daniel J Rosenberg, Michal Hammel, Benjamin A Adler, Marco J Lobba, Michael Xu, Adam P Arkin, Christof Fellmann, Jennifer A Doudna
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
CRISPR-Cas
anti-CRISPR
bacteriophage
Online Access:https://elifesciences.org/articles/49110

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