Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats

Abstract The Sodium Glucose Co-Transporter-2 inhibitor, empagliflozin (EMPA), reduces mortality and hospitalisation for heart failure following myocardial infarction irrespective of diabetes status. While the findings suggest an inherent cardioprotective capacity, the mechanism remains unknown. We s...

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Bibliographic Details
Main Authors: Jacob Marthinsen Seefeldt, Thomas Ravn Lassen, Marie Vognstoft Hjortbak, Nichlas Riise Jespersen, Frederikke Kvist, Jakob Hansen, Hans Erik Bøtker
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89149-9