PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor

Abstract Background Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable indolent growth with malignant potential and late recurrence. Approximately 95% are of adult type. Recent molecular studies have characterized the FOXL2 402C > G mutation in adult...

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Bibliographic Details
Main Authors: Wen-Chung Wang, Ya-Ting Lee, Yen-Chein Lai
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Journal of Ovarian Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13048-017-0317-4