A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in tandem with primary hair follicles and contain sensory Merkel cells. The developmental signaling requirements for touch dome specification ar...

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Bibliographic Details
Main Authors: Ying Xiao, Daniel T Thoresen, Lingling Miao, Jonathan S Williams, Chaochen Wang, Radhika P Atit, Sunny Y Wong, Isaac Brownell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1006150