Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch

Abstract Background Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-translational modification system. In the adaptive immune response, B c...

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Bibliographic Details
Main Authors: Shannon P Hilchey, Mukta G Palshikar, Jason A Emo, Dongmei Li, Jessica Garigen, Jiong Wang, Eric S Mendelson, Valentina Cipolla, Juilee Thakar, Martin S Zand
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Immunology
Subjects:
HIF-1 α
Hypoxia
B cells
CXCR4/CXCL12
CXCR5/CXCL13
Chemotaxis
Online Access:http://link.springer.com/article/10.1186/s12865-020-0342-8

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http://link.springer.com/article/10.1186/s12865-020-0342-8

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