Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins

Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins

A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary functionalities for further transformations. Th...

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Bibliographic Details
Main Authors: Robby Vroemans, Fante Bamba, Jonas Winters, Joice Thomas, Jeroen Jacobs, Luc Van Meervelt, Jubi John, Wim Dehaen
Format: Article
Language:English
Published: Beilstein-Institut 2018-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
benzodiazepine
2,5-diketopiperazine
hydantoin
intramolecular azide–alkyne cycloaddition
Ugi reaction
Online Access:https://doi.org/10.3762/bjoc.14.49

Internet

https://doi.org/10.3762/bjoc.14.49

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