Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10

Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10

Inflammatory bowel disease (IBD) and Clostridium difficile infection cause gastrointestinal (GI) distension and, in severe cases, toxic megacolon with risk of perforation and death. Herpesviruses have been linked to severe GI dilatation. MHV-68 is a model for human gamma herpesvirus infection induci...

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Bibliographic Details
Main Authors: Hao Chen, Mee Yong Bartee, Jordan R. Yaron, Liying Liu, Liqiang Zhang, Donghang Zheng, Ian B. Hogue, Whitney L. Bullard, Scott Tibbetts, Alexandra R. Lucas
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Viruses
Subjects:
MHV-68
gamma herpesvirus
Interleukin-10
macrophage
gastrointestinal
toxic megacolon
Online Access:http://www.mdpi.com/1999-4915/10/10/518

Internet

http://www.mdpi.com/1999-4915/10/10/518

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