NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma

NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma

Abstract CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma cells. CARs can be designed through the use of receptors, such as NKG2D, which recognizes a wide range of liga...

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Bibliographic Details
Main Authors: Alejandra Leivas, Antonio Valeri, Laura Córdoba, Almudena García-Ortiz, Alejandra Ortiz, Laura Sánchez-Vega, Osvaldo Graña-Castro, Lucía Fernández, Gonzalo Carreño-Tarragona, Manuel Pérez, Diego Megías, María Liz Paciello, Jose Sánchez-Pina, Antonio Pérez-Martínez, Dean A. Lee, Daniel J. Powell, Paula Río, Joaquín Martínez-López
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-021-00537-w

Internet

https://doi.org/10.1038/s41408-021-00537-w

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