Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Abstract Background The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune cell recruitment and activation. Impor...

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Bibliographic Details
Main Authors: Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff, Peter G. Noakes
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Skeletal Muscle
Subjects:
Complement
C5
C5aR1
Inflammation
Macrophages
Skeletal muscle
Online Access:http://link.springer.com/article/10.1186/s13395-017-0128-8

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http://link.springer.com/article/10.1186/s13395-017-0128-8

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