Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions

Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions

The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence motifs, dynamic interactions, or conf...

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Bibliographic Details
Main Author: Monika Fuxreiter
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
protein dynamics
conformational heterogeneity
promiscuity
fuzzy complexes
higher-order structures
protein evolution
fuzzy set theory
artificial intelligence
Online Access:https://www.mdpi.com/1420-3049/23/11/3008

Internet

https://www.mdpi.com/1420-3049/23/11/3008

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