Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system.

Bibliographic Details
Main Authors: Grégoire Chevalier, Eleni Siopi, Laure Guenin-Macé, Maud Pascal, Thomas Laval, Aline Rifflet, Ivo Gomperts Boneca, Caroline Demangel, Benoit Colsch, Alain Pruvost, Emeline Chu-Van, Aurélie Messager, François Leulier, Gabriel Lepousez, Gérard Eberl, Pierre-Marie Lledo
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19931-2

Internet

https://doi.org/10.1038/s41467-020-19931-2

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