Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

Friedreich’s Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder, affecting dorsal root ganglia (DRG), cerebellar dentate nuclei and heart. It is caused by a GAA repeat expansion mutation within the frataxin gene (FXN). This impedes FXN transcription resulting in a progressive decreas...

Full description

Bibliographic Details
Main Authors: Rosella Abeti, Annalisa Baccaro, Noemi Esteras, Paola Giunti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Friedreich’s ataxia
reactive oxygen species
lipid peroxidation
mitochondrial dysfunction
human fibroblasts
nuclear factor (erythroid-derived 2)-like 2
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00188/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00188/full

Similar Items