The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

<p>Abstract</p> <p>Background</p> <p>Key molecules involved in notochord differentiation and function have been identified through genetic analysis in zebrafish and mice, but MEK1 and 2 have so far not been implicated in this process due to early lethality (<it>Me...

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Bibliographic Details
Main Authors: Szabó Gábor, Erdélyi Ferenc, Cavodeassi Florencia, Hawkins Thomas A, Lele Zsolt
Format: Article
Language:English
Published: BMC 2008-04-01
Series:BMC Developmental Biology
Online Access:http://www.biomedcentral.com/1471-213X/8/42