True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors

Summary: Signaling nanodomains rely on spatial organization of proteins to allow controlled intracellular signaling. Examples include calcium release sites of cardiomyocytes where ryanodine receptors (RyRs) are clustered with their molecular partners. Localization microscopy has been crucial to visu...

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Bibliographic Details
Main Authors: Isuru Jayasinghe, Alexander H. Clowsley, Ruisheng Lin, Tobias Lutz, Carl Harrison, Ellen Green, David Baddeley, Lorenzo Di Michele, Christian Soeller
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318697