MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein

MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein

Niemann-Pick Type C (NPC) disease is a fatal, neurodegenerative disorder, caused in most cases by mutations in the late endosomal protein NPC1. A hallmark of NPC disease is endosomal cholesterol accumulation and an impaired cholesterol homeostatic response, which might affect cholesterol transport t...

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Bibliographic Details
Main Authors: Mark Charman, Barry E. Kennedy, Nolan Osborne, Barbara Karten
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Journal of Lipid Research
Subjects:
mitochondrial cholesterol
STAR-related lipid transfer domain
steroidogenic acute regulatory protein
pregnenolone
steroids
oxysterols
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410582

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http://www.sciencedirect.com/science/article/pii/S0022227520410582

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