Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease

Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease

The mineralocorticoid hormone aldosterone regulates sodium and potassium homeostasis but also adversely modulates the maladaptive process of cardiac adverse remodeling post-myocardial infarction. Through activation of its mineralocorticoid receptor (MR), a classic steroid hormone receptor/transcript...

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Bibliographic Details
Main Authors: Barbara M. Parker, Shelby L. Wertz, Celina M. Pollard, Victoria L. Desimine, Jennifer Maning, Katie A. McCrink, Anastasios Lymperopoulos
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
adverse remodeling
aldosterone
cardiac myocyte
crosstalk
G protein-coupled receptor (GPCR)
GPCR-kinase (GRK)
heart failure
inflammation
mineralocorticoid receptor
myocardial infarction
oxidative stress
signal transduction
Online Access:https://www.mdpi.com/1422-0067/19/12/3764

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https://www.mdpi.com/1422-0067/19/12/3764

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