Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species

Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species

The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, colony formation, migration, ROS production, and the...

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Bibliographic Details
Main Authors: Ukjin Kim, C-Yoon Kim, Ji Min Lee, Bokyeong Ryu, Jin Kim, Changsoo Shin, Jae-Hak Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
pimozide
drug repurposing
prostate neoplasm
reactive oxygen species
TRAMP
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01517/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01517/full

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