Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.

Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.

DNA replication and transcription are vital cellular processes during which the genetic information is copied into complementary DNA and RNA molecules. Highly complex machineries required for DNA and RNA synthesis compete for the same DNA template, therefore being on a collision course. Unscheduled...

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Bibliographic Details
Main Authors: Alessandra eBrambati, Arianna eColosio, Luca eZardoni, Lorenzo eGalanti, Giordano eLiberi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Genetics
Subjects:
Cancer
neurodegeneration
genetic instability
replication stress
R-loops
Epigenetic instability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00166/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00166/full

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