Activation of apoptotic pathways at muscle fiber synapses is circumscribed and reversible in a slow-channel syndrome model

Activation of apoptotic pathways at muscle fiber synapses is circumscribed and reversible in a slow-channel syndrome model

In the slow-channel syndrome (SCS) mutant acetylcholine receptors elicit calcium overload and myonuclear degeneration at the neuromuscular junction (NMJ), without muscle fiber death. Activated caspases are present at SCS motor endplates. We hypothesized that SCS represents a limited form of apoptosi...

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Bibliographic Details
Main Authors: Bhupinder P.S. Vohra, Jason S. Groshong, Roberto Zayas, Robert L. Wollmann, Christopher M. Gomez
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Caspase
Apoptosis
Channelopathy
Mutation
Acetylcholine receptor
Neuromuscular junction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000830

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http://www.sciencedirect.com/science/article/pii/S0969996106000830

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