The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1.

Breaking the balance between proliferation and differentiation in animal cells can lead to cancer, but the mechanisms maintaining this balance remain largely undefined. The calcium activated chloride channel A1 (CLCA1) is a member of the calcium sensitive chloride conductance family of proteins and...

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Bibliographic Details
Main Authors: Bo Yang, Lin Cao, Bin Liu, Colin D McCaig, Jin Pu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3625186?pdf=render