Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease

Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease

Cerebral organoids (COs) are a self-organizing three-dimensional brain tissue mimicking the human cerebral cortex. COs are a promising new system for modelling pathological features of neurological disorders, including prion diseases. COs expressing normal prion protein (PrPC) are susceptible to pri...

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Bibliographic Details
Main Authors: Simote T. Foliaki, Bradley R. Groveman, Jue Yuan, Ryan Walters, Shulin Zhang, Paul Tesar, Wenquan Zou, Cathryn L. Haigh
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pathogens
Subjects:
prion
CJD
E200K
cerebral organoid
iPSC
Online Access:https://www.mdpi.com/2076-0817/9/6/482

Internet

https://www.mdpi.com/2076-0817/9/6/482

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