Immunotherapy reversed myopathy but not cardiomyopathy in a necrotizing autoimmune myopathy patient with positive anti-SRP and MDA-5 autoantibodies

Immunotherapy reversed myopathy but not cardiomyopathy in a necrotizing autoimmune myopathy patient with positive anti-SRP and MDA-5 autoantibodies

Abstract Background Necrotizing autoimmune myopathy (NAM) is pathologically characterized by myofiber necrosis and regeneration with paucity or absence of inflammatory cells in muscle biopsy. Two autoantibodies, namely anti-signal recognition particle (SRP)-antibodies and anti-3-hydroxy-3-methylglut...

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Bibliographic Details
Main Authors: Xue Ma, Li Xu, Yue Li, Bitao Bu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cardiovascular Disorders
Subjects:
Anti-SRP and anti-MDA5 positive NAM
Cardiomyopathy
Heart transplantation
Autophagy
Apoptosis
Online Access:https://doi.org/10.1186/s12872-021-01900-2

Internet

https://doi.org/10.1186/s12872-021-01900-2

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