Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner–Wadsworth–Emmons-based approach

Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner–Wadsworth–Emmons-based approach

Integrin inhibitors based on the tripeptide sequence Arg–Gly–Asp (RGD) are potential therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF). Herein, we describe an expeditious three-step synthetic sequence of Horner–Wadsworth–Emmons olefination, diimide reduction, and global deprotect...

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Bibliographic Details
Main Authors: Rhys A. Lippa, John A. Murphy, Tim N. Barrett
Format: Article
Language:English
Published: Beilstein-Institut 2020-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
arginine
horner–wadsworth–emmons
integrin
phosphoramidate
tetrahydronaphthyridine
Online Access:https://doi.org/10.3762/bjoc.16.134

Internet

https://doi.org/10.3762/bjoc.16.134

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