Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

The pathogenesis of heparin-induced thrombocytopenia and thrombosis (HIT) is mediated by heparin-reactive autoantibodies binding to platelets (thrombocytes). Here the authors show neutrophil activation and NETosis are elevated in patients with HIT, and are essential for thrombosis in HIT mouse model...

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Bibliographic Details
Main Authors: José Perdomo, Halina H. L. Leung, Zohra Ahmadi, Feng Yan, James J. H. Chong, Freda H. Passam, Beng H. Chong
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09160-7

Internet

https://doi.org/10.1038/s41467-019-09160-7

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