Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury

Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury

Cyclopentenone prostaglandins (CyPGs), such as 15-deoxy-Δ12,14 -prostaglandin J2 (15d-PGJ2), are active prostaglandin metabolites exerting a variety of biological effects that may be important in the pathogenesis of neurological diseases. Ubiquitin-C-terminal hydrolase L1 (UCH-L1) is a brain specifi...

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Bibliographic Details
Main Authors: Hao Liu, Wenjin Li, Muzamil Ahmad, Tricia M. Miller, Marie E. Rose, Samuel M. Poloyac, Guy Uechi, Manimalha Balasubramani, Robert W. Hickey, Steven H. Graham
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Ubiquitin–proteasome pathway
Ubiquitin–C-terminal hydrolase L1
Cyclopentenone prostaglandins
Protein post-translational modification
Arachidonic acid
Hypoxic neuronal injury
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000330X

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http://www.sciencedirect.com/science/article/pii/S096999611000330X

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