Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

The exclusion of cytotoxic T cells remains an important barrier to the efficacy of immunotherapies. Here the authors demonstrate that the combination anti-fibrosis agents and immune-enhanced cytokines can enhance T cell infiltration in a mouse model of pancreatic cancer.

Bibliographic Details
Main Authors: Yukun Huang, Yu Chen, Songlei Zhou, Liang Chen, Jiahao Wang, Yuanyuan Pei, Minjun Xu, Jingxian Feng, Tianze Jiang, Kaifan Liang, Shanshan Liu, Qingxiang Song, Gan Jiang, Xiao Gu, Qian Zhang, Xiaoling Gao, Jun Chen
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14425-7

Internet

https://doi.org/10.1038/s41467-020-14425-7

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