Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection.

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection.

The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pestis CO92 by macrophages and the subsequent activatio...

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Bibliographic Details
Main Authors: Krishna P Kota, Brett Eaton, Douglas Lane, Melanie Ulrich, Ricky Ulrich, Brian D Peyser, Camenzind G Robinson, James G Jaissle, Gianluca Pegoraro, Sina Bavari, Rekha G Panchal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3559335?pdf=render

Internet

http://europepmc.org/articles/PMC3559335?pdf=render

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