CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

Summary: Targeting solid tumors must overcome several major obstacles, in particular, the identification of elusive tumor-specific antigens. Here, we devise a strategy to help identify tumor-specific epitopes. Glypican 2 (GPC2) is overexpressed in neuroblastoma. Using RNA sequencing (RNA-seq) analys...

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Bibliographic Details
Main Authors: Nan Li, Madeline B. Torres, Madeline R. Spetz, Ruixue Wang, Luyi Peng, Meijie Tian, Christopher M. Dower, Rosa Nguyen, Ming Sun, Chin-Hsien Tai, Natalia de Val, Raul Cachau, Xiaolin Wu, Stephen M. Hewitt, Rosandra N. Kaplan, Javed Khan, Brad St Croix, Carol J. Thiele, Mitchell Ho
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports Medicine
Subjects:
glypican 2
pediatric cancers
immunotherapy
tumor-specific T cells
antibodies
electron microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001300

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http://www.sciencedirect.com/science/article/pii/S2666379121001300

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