Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

Abstract Background Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor blockade by which these antibodies prevent CGRP signaling through CGRP rece...

Full description

Bibliographic Details
Main Authors: Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan, Cen Xu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:The Journal of Headache and Pain
Subjects:
Calcitonin gene-related peptide
CGRP receptor
CGRP receptor antagonist antibody
Migraine
Receptor trafficking
Receptor recycling
Online Access:http://link.springer.com/article/10.1186/s10194-019-0992-1

Internet

http://link.springer.com/article/10.1186/s10194-019-0992-1

Similar Items