Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin

Bo AhrénDepartment of Clinical Sciences, Lund University, Lund, SwedenAbstract: Inhibition of dipeptidyl peptidase-4 (DPP-4) prevents the inactivation of glucagonlike peptide-1 (GLP-1). This increases circulating levels of active GLP-1, stimulates insulin secretion and inhibits glucag...

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Bibliographic Details
Main Author: Bo Ahrén
Format: Article
Language:English
Published: Dove Medical Press 2010-03-01
Series:Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Online Access:http://www.dovepress.com/use-of-dpp-4-inhibitors-in-type-2-diabetes-focus-on-sitagliptin-a4147