Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.

Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.

Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the actio...

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Main Authors: Ling Yi, Yanlin Zhao, Xiaojue Wang, Min Dai, Karl Erik Hellström, Ingegerd Hellström, Hongtao Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897701?pdf=render
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spelling doaj-15429aec82df4a3a972e97815f52a9002020-11-25T02:50:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8633710.1371/journal.pone.0086337Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.Ling YiYanlin ZhaoXiaojue WangMin DaiKarl Erik HellströmIngegerd HellströmHongtao ZhangMonoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the action of agonistic and antagonistic anti-CD137 mAbs we have mapped the binding region of the CD137 ligand (CD137L) to human and mouse CD137. By investigating the binding of CD137L to cysteine rich domain II (CRDII )and CRDIII of CD137, we found that the binding interface was limited and differed between the two species in that mouse CD137L mainly combined with CRDII and human CD137L mainly combined with CRDIII.http://europepmc.org/articles/PMC3897701?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Ling Yi
Yanlin Zhao
Xiaojue Wang
Min Dai
Karl Erik Hellström
Ingegerd Hellström
Hongtao Zhang
spellingShingle Ling Yi
Yanlin Zhao
Xiaojue Wang
Min Dai
Karl Erik Hellström
Ingegerd Hellström
Hongtao Zhang
Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
PLoS ONE
author_facet Ling Yi
Yanlin Zhao
Xiaojue Wang
Min Dai
Karl Erik Hellström
Ingegerd Hellström
Hongtao Zhang
author_sort Ling Yi
title Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
title_short Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
title_full Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
title_fullStr Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
title_full_unstemmed Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
title_sort human and mouse cd137 have predominantly different binding crds to their respective ligands.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the action of agonistic and antagonistic anti-CD137 mAbs we have mapped the binding region of the CD137 ligand (CD137L) to human and mouse CD137. By investigating the binding of CD137L to cysteine rich domain II (CRDII )and CRDIII of CD137, we found that the binding interface was limited and differed between the two species in that mouse CD137L mainly combined with CRDII and human CD137L mainly combined with CRDIII.
url http://europepmc.org/articles/PMC3897701?pdf=render
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AT yanlinzhao humanandmousecd137havepredominantlydifferentbindingcrdstotheirrespectiveligands
AT xiaojuewang humanandmousecd137havepredominantlydifferentbindingcrdstotheirrespectiveligands
AT mindai humanandmousecd137havepredominantlydifferentbindingcrdstotheirrespectiveligands
AT karlerikhellstrom humanandmousecd137havepredominantlydifferentbindingcrdstotheirrespectiveligands
AT ingegerdhellstrom humanandmousecd137havepredominantlydifferentbindingcrdstotheirrespectiveligands
AT hongtaozhang humanandmousecd137havepredominantlydifferentbindingcrdstotheirrespectiveligands
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