Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.

by Ling Yi, Yanlin Zhao, Xiaojue Wang, Min Dai, Karl Erik Hellström, Ingegerd Hellström, Hongtao Zhang
Published 2014-01-01

Combinatorial PD-1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin.

by Huafeng Wei, Likun Zhao, Wei Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Min Dai, Ingegerd Hellstrom, Karl Erik Hellstrom, Yajun Guo
Published 2013-01-01