Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy

Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy

Neuroinflammatory processes play an integral role in the exacerbation and progression of pathology in tauopathies, a class of neurodegenerative disease characterized by aggregation of hyperphosphorylated tau protein. The RNA binding protein (RBP) T-cell Intracellular Antigen 1 (TIA1) is an important...

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Bibliographic Details
Main Authors: Chelsey Jenna LeBlang, Maria Medalla, Nicholas William Nicoletti, Emma Catherine Hays, James Zhao, Jenifer Shattuck, Anna Lourdes Cruz, Benjamin Wolozin, Jennifer Irene Luebke
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
tauopathy
neuroinflammation
microglia
hippocampus
RNA binding protein
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00285/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00285/full

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