Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells
Tumor-initiating cells, also designated as cancer stem cells, are proposed to constitute a subpopulation of malignant cells central to tumorigenesis, metastasis, and treatment resistance. We analyzed the activity of the proteasome, the primary organelle for targeted protein degradation, as a marker...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi - SAGE Publishing
2015-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2015.00016 |