Ciliary Neurotrophic Factor Acts on Distinctive Hypothalamic Arcuate Neurons and Promotes Leptin Entry Into and Action on the Mouse Hypothalamus

Ciliary Neurotrophic Factor Acts on Distinctive Hypothalamic Arcuate Neurons and Promotes Leptin Entry Into and Action on the Mouse Hypothalamus

In humans and experimental animals, the administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight. To gain further insights into the mechanism(s) underlying its satiety effect, we: (i) evaluated the CNTF-dependent activation of the Janus kinase 2 (JAK2) and signal tran...

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Bibliographic Details
Main Authors: Wiebe Venema, Ilenia Severi, Jessica Perugini, Eleonora Di Mercurio, Marco Mainardi, Margherita Maffei, Saverio Cinti, Antonio Giordano
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
arcuate nucleus
AgRP neurons
NPY neurons
tanycytes
median eminence
obesity
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00140/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00140/full

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