Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription
Cell proliferation is regulated by cyclin-dependent kinases (Cdks) and relies on periodic gene cluster expression according to cell cycle phases. Here the authors use a synthetic regulatable Cdk1 module to demonstrate that periodic expression is governed by quantitative changes in Cdk1 activity.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11161 |