Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in m...

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Main Authors: Teresa Pérez-Berezo, Julien Pujo, Patricia Martin, Pauline Le Faouder, Jean-Marie Galano, Alexandre Guy, Claude Knauf, Jean Claude Tabet, Sophie Tronnet, Frederick Barreau, Maud Heuillet, Gilles Dietrich, Justine Bertrand-Michel, Thierry Durand, Eric Oswald, Nicolas Cenac
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01403-9
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spelling doaj-14fbaec632884e6fbafc02bc5cea62fa2021-05-11T07:33:54ZengNature Publishing GroupNature Communications2041-17232017-11-018111210.1038/s41467-017-01403-9Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917Teresa Pérez-Berezo0Julien Pujo1Patricia Martin2Pauline Le Faouder3Jean-Marie Galano4Alexandre Guy5Claude Knauf6Jean Claude Tabet7Sophie Tronnet8Frederick Barreau9Maud Heuillet10Gilles Dietrich11Justine Bertrand-Michel12Thierry Durand13Eric Oswald14Nicolas Cenac15IRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierMetaToulLipidomics Facility, INSERM UMR1048Institut des Biomolécules Max Mousseron IBMM, UMR 5247 CNRS, Université de Montpellier-ENSCMInstitut des Biomolécules Max Mousseron IBMM, UMR 5247 CNRS, Université de Montpellier-ENSCMIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierSorbonne Université, UPMC Univ Paris 06, CNRS, Institut Parisien de Chimie Moléculaire (IPCM)IRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierLISBP, Université de Toulouse, CNRS, INRA, INSAIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierMetaToulLipidomics Facility, INSERM UMR1048Institut des Biomolécules Max Mousseron IBMM, UMR 5247 CNRS, Université de Montpellier-ENSCMIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierIRSD, Université de Toulouse, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul SabatierEscherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.https://doi.org/10.1038/s41467-017-01403-9
collection DOAJ
language English
format Article
sources DOAJ
author Teresa Pérez-Berezo
Julien Pujo
Patricia Martin
Pauline Le Faouder
Jean-Marie Galano
Alexandre Guy
Claude Knauf
Jean Claude Tabet
Sophie Tronnet
Frederick Barreau
Maud Heuillet
Gilles Dietrich
Justine Bertrand-Michel
Thierry Durand
Eric Oswald
Nicolas Cenac
spellingShingle Teresa Pérez-Berezo
Julien Pujo
Patricia Martin
Pauline Le Faouder
Jean-Marie Galano
Alexandre Guy
Claude Knauf
Jean Claude Tabet
Sophie Tronnet
Frederick Barreau
Maud Heuillet
Gilles Dietrich
Justine Bertrand-Michel
Thierry Durand
Eric Oswald
Nicolas Cenac
Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
Nature Communications
author_facet Teresa Pérez-Berezo
Julien Pujo
Patricia Martin
Pauline Le Faouder
Jean-Marie Galano
Alexandre Guy
Claude Knauf
Jean Claude Tabet
Sophie Tronnet
Frederick Barreau
Maud Heuillet
Gilles Dietrich
Justine Bertrand-Michel
Thierry Durand
Eric Oswald
Nicolas Cenac
author_sort Teresa Pérez-Berezo
title Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_short Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_full Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_fullStr Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_full_unstemmed Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_sort identification of an analgesic lipopeptide produced by the probiotic escherichia coli strain nissle 1917
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.
url https://doi.org/10.1038/s41467-017-01403-9
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