Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in m...

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Bibliographic Details
Main Authors: Teresa Pérez-Berezo, Julien Pujo, Patricia Martin, Pauline Le Faouder, Jean-Marie Galano, Alexandre Guy, Claude Knauf, Jean Claude Tabet, Sophie Tronnet, Frederick Barreau, Maud Heuillet, Gilles Dietrich, Justine Bertrand-Michel, Thierry Durand, Eric Oswald, Nicolas Cenac
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01403-9

Internet

https://doi.org/10.1038/s41467-017-01403-9

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