Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy

Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy

Highlights 1. PRP enhances cell viability and osteogenic differentiation of hPDLSCs. 2. Activated PRP dose-dependently increases cell autophagy. 3. Inhibition of autophagy abrogates PRP-induced osteogenic differentiation of hPDLSCs.

Bibliographic Details
Main Authors: Yunhe Xu, Xiaoning Wang, Wenshu Liu, Weiwei Lu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:European Journal of Medical Research
Subjects:
Autophagy
Osteogenic differentiation
Periodontal ligament stem cells
Platelet-rich plasma
Viability
Online Access:https://doi.org/10.1186/s40001-021-00575-x

Internet

https://doi.org/10.1186/s40001-021-00575-x

Similar Items