Neopterin suppresses the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase in human peripheral blood mononuclear cells

Neopterin suppresses the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase in human peripheral blood mononuclear cells

In vitro, large amounts of neopterin are released from human monocyte-derived macrophages and dendritic cells primarily upon stimulation with Th1-type cytokine interferon-γ (IFN-γ). IFN-γ also induces the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (TRP) to form kynurenine (K...

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Bibliographic Details
Main Authors: Schroecksnadel Sebastian, Ledjeff Elena-Sophia, Gostner Johanna, Winkler Christiana, Kurz Katharina, Schennach Harald, Fuchs Dietmar
Format: Article
Language:English
Published: De Gruyter 2013-12-01
Series:Pteridines
Subjects:
indoleamine 2,3-dioxygenase
macrophages
neopterin
t-cell activation
Online Access:https://doi.org/10.1515/pterid-2013-0037

Internet

https://doi.org/10.1515/pterid-2013-0037

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