Multivalent electrostatic pi–cation interaction between synaptophysin and synapsin is responsible for the coacervation

Multivalent electrostatic pi–cation interaction between synaptophysin and synapsin is responsible for the coacervation

Abstract We recently showed that synaptophysin (Syph) and synapsin (Syn) can induce liquid–liquid phase separation (LLPS) to cluster small synaptic-like microvesicles in living cells which are highly reminiscent of SV cluster. However, as there is no physical interaction between them, the underlying...

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Bibliographic Details
Main Authors: Goeun Kim, Sang-Eun Lee, Seonyoung Jeong, Jeongkun Lee, Daehun Park, Sunghoe Chang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Brain
Subjects:
Synaptophysin
Synapsin
Liquid–liquid phase separation (LLPS)
Pi–cation interactions
Synaptic vesicle cluster
Presynaptic nerve terminals
Online Access:https://doi.org/10.1186/s13041-021-00846-y

Internet

https://doi.org/10.1186/s13041-021-00846-y

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