Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss.

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss.

BACKGROUND:Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarriage. Mouse models allow us to investigate how def...

Full description

Bibliographic Details
Main Authors: Catriona Paul, Joanne E Povey, Nicola J Lawrence, Jim Selfridge, David W Melton, Philippa T K Saunders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1991594?pdf=render

Internet

http://europepmc.org/articles/PMC1991594?pdf=render

Similar Items