Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells

Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells

Gonadotropin-releasing hormone (GnRH) neurons regulate human puberty and reproduction. Modeling their development and function in vitro would be of interest for both basic research and clinical translation. Here, we report a three-step protocol to differentiate human pluripotent stem cells (hPSCs) i...

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Bibliographic Details
Main Authors: Carina Lund, Kristiina Pulli, Venkatram Yellapragada, Paolo Giacobini, Karolina Lundin, Sanna Vuoristo, Timo Tuuri, Parinya Noisa, Taneli Raivio
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Stem Cell Reports
Subjects:
human pluripotent stem cells
induced pluripotent stem cells
human embryonic stem cells
gonadotropin-releasing hormone
GnRH
puberty
hypogonadotropic hypogonadism
Kallmann syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116300996

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http://www.sciencedirect.com/science/article/pii/S2213671116300996

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