Model-based optimization of the primary drying phase of oral lyophilizates

Oral lyophilizates also called orally disintegrating tablets (ODTs) are a patient friendly and convenient dosage form. They are manufactured by dosing a suspension in blister cups and subsequently freeze-drying these blisters to achieve porous tablets that disintegrate quickly (< 10 s) when place...

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Bibliographic Details
Main Authors: Brecht Vanbillemont, Thomas De Beer
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156720300190