High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor.

High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor.

In vivo direct conversion of differentiated cells holds promise for regenerative medicine; however, improving the conversion efficiency and producing functional target cells remain challenging. Ectopic Atoh1 expression in non-sensory supporting cells (SCs) in mouse cochleae induces their partial con...

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Bibliographic Details
Main Authors: Tetsuji Yamashita, Fei Zheng, David Finkelstein, Zoe Kellard, Robert Carter, Celeste D Rosencrance, Ken Sugino, John Easton, Charles Gawad, Jian Zuo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6086484?pdf=render

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http://europepmc.org/articles/PMC6086484?pdf=render

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