Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway

Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway

Background/Aims: Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN), secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic properties in various cell types. This study aimed to investigate the role of...

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Bibliographic Details
Main Authors: Junzheng Hu, Weiding Cui, Wenxiao Ding, Yanqing Gu, Zhen Wang, Weimin Fan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Adiponectin
Chondrocytes
Autophagy
Apoptosis
AMPK
Online Access:http://www.karger.com/Article/FullText/480416

Internet

http://www.karger.com/Article/FullText/480416

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