Insulin Secretion in Response to L-Arginine under Decreasing Tetrahydrobiopterin Content

Insulin Secretion in Response to L-Arginine under Decreasing Tetrahydrobiopterin Content

Tetrahydrobiopterin (BH4) content in the pancreas from GK (Goto-Kakizaki) rats as a type II diabetic model was markedly decreased compared to Wistar rats as a healthy control. Moreover, insulin stimulated BH4 synthesis in a hamster pancreatic β-cell line, HIT-T15 cells. Therefore, in diabetic condit...

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Bibliographic Details
Main Authors: Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji
Format: Article
Language:English
Published: De Gruyter 2008-02-01
Series:Pteridines
Subjects:
tetrahydrobiopterin
nitric oxide
calcium
l-arginine
insulin
β-cell
Online Access:https://doi.org/10.1515/pteridines.2008.19.1.93

Internet

https://doi.org/10.1515/pteridines.2008.19.1.93

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