Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders

Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders

New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied. The novel compounds showed strong, micromolar an...

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Bibliographic Details
Main Authors: Ivana Mikulin, Ivana Ljubić, Ivo Piantanida, Aleksey Vasilev, Mihail Mondeshki, Meglena Kandinska, Lidija Uzelac, Irena Martin-Kleiner, Marijeta Kralj, Lidija-Marija Tumir
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
cyanine dye
DNA binding
RNA binding
fluorescence
circular dichroism
antiproliferative activity
Online Access:https://www.mdpi.com/2218-273X/11/8/1075

Internet

https://www.mdpi.com/2218-273X/11/8/1075

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